Octet

Octet / Reagents

Gilman Reagent (Cuprate)

Gilman Reagent (Cuprate) (R₂CuLi) - nucleophile reagent. Conjugate addition and coupling. Common uses: 1,4-addition to enones (not 1,2), Coupling with alkyl halides. Softer nucleophile than Grignard/organolithium. Prefers conjugate addition.

Nucleophile

Reagent details

Name

Gilman Reagent (Cuprate)

Formula

R₂CuLi

Category

Nucleophile

Function

Conjugate addition and coupling

Common Uses

  1. 1,4-addition to enones (not 1,2)

  2. Coupling with alkyl halides

Notes

Softer nucleophile than Grignard/organolithium. Prefers conjugate addition.

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Reagents

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