Octet

Octet / Reagents

Grignard Reagent

Grignard Reagent (RMgBr (or RMgCl)) - nucleophile reagent. Carbon nucleophile for C-C bond formation. Common uses: Aldehyde + RMgBr → 2° alcohol, Ketone + RMgBr → 3° alcohol, Formaldehyde + RMgBr → 1° alcohol, CO₂ + RMgBr → Carboxylic acid, Epoxide + RMgBr →...

Nucleophile

Reagent details

Name

Grignard Reagent

Formula

RMgBr (or RMgCl)

Category

Nucleophile

Function

Carbon nucleophile for C-C bond formation

Common Uses

  1. Aldehyde + RMgBr → 2° alcohol

  2. Ketone + RMgBr → 3° alcohol

  3. Formaldehyde + RMgBr → 1° alcohol

  4. CO₂ + RMgBr → Carboxylic acid

  5. Epoxide + RMgBr → Alcohol (2 carbons added)

Notes

Strictly anhydrous! Made from R-X + Mg in ether. Very basic and nucleophilic.

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Reagents

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