Octet / Reactions
Michael Addition
Michael Addition (Conjugate Addition Carbonyl.) Converts CC(=O)C=C to CC(=O)CCC#N using Nucleophile (enolate, CN⁻, amine, thiol).
Carbonyl
Reaction details
Name
Michael Addition
Type
Carbonyl
Subtype
Conjugate Addition
Starting Material
CC(=O)C=C
Product
CC(=O)CCC#N
Reagents
Nucleophile (enolate, CN⁻, amine, thiol)
Mechanism
- Smiles
CC(=O)C=C
- Description
α,β-unsaturated ketone (MVK)
- Smiles
CC(=O)CCC#N
- Description
Nucleophile added to β-carbon (1,4-addition)
Tips
Conjugate (1,4) addition to α,β-unsaturated carbonyl
Soft nucleophiles prefer conjugate addition
Hard nucleophiles prefer 1,2-addition to C=O
Related Reactions
aldol-addition
This is one row of the Reaction roadmap sheet - print all 83 reactions on one page.