Octet / Reactions
Swern Oxidation
Swern Oxidation (Oxidation.) Converts CCO to CC=O using (COCl)₂ (oxalyl chloride), DMSO, Et₃N. Conditions: -78°C.
Oxidation
Reaction details
Name
Swern Oxidation
Type
Oxidation
Starting Material
CCO
Product
CC=O
Reagents
(COCl)₂ (oxalyl chloride)
DMSO
Et₃N
Conditions
-78°C
Mechanism
- Smiles
CCO
- Description
Primary alcohol
- Smiles
CC=O
- Description
Aldehyde (no over-oxidation)
Tips
No heavy metals (unlike PCC, Jones)
Very mild conditions
Stops at aldehyde
Bad smell from DMSO byproduct
Related Reactions
pcc-oxidation
dess-martin-oxidation
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